Sex differences in histopathological markers of cerebral amyloid angiopathy and related hemorrhage.

ABSTRACT:

Background

Men with cerebral amyloid angiopathy (CAA) may have an earlier onset of intracerebral hemorrhage and a more hemorrhagic disease course compared to women. In this cohort study, we investigated sex differences in histopathological markers associated with amyloid-β burden and hemorrhage in cognitively impaired individuals and patients with CAA, using neuropathological data from two autopsy databases.

Methods

First, we investigated presence of parenchymal (Thal score) and vascular amyloid-β (CAA severity score) in cognitively impaired individuals from the National Alzheimer's Coordinating Center (NACC) neuropathology database. Next, we examined sex differences in hemorrhagic ex vivo magnetic resonance imaging (MRI) markers and local cortical iron burden and the intera

SUBMITTER: Koemans EA 

PROVIDER: S-EPMC11408965 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature