Unveiling differential gene co-expression networks and its effects on levodopa-induced dyskinesia.

ABSTRACT: Levodopa-induced dyskinesia (LID) refers to involuntary motor movements of chronic use of levodopa in Parkinson's disease (PD) that negatively impact the overall well-being of people with this disease. The molecular mechanisms involved in LID were investigated through whole-blood transcriptomic analysis for differential gene expression and identification of new co-expression and differential co-expression networks. We found six differentially expressed genes in patients with LID, and 13 in patients without LID. We also identified 12 co-expressed genes exclusive to LID, and six exclusive hub genes involved in 23 gene-gene interactions in patients with LID. Convergently, we identified novel genes associated with PD and LID that play roles in mitochondrial dysfunction, dysregulation of lipid

SUBMITTER: Piedade de Souza T 

PROVIDER: S-EPMC11409023 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature