Eomes expression identifies the early bone marrow precursor to classical NK cells.

ABSTRACT: Natural killer (NK) cells traffic through the blood and mount cytolytic and interferon-γ (IFNγ)-focused responses to intracellular pathogens and tumors. Type 1 innate lymphoid cells (ILC1s) also produce type 1 cytokines but reside in tissues and are not cytotoxic. Whether these differences reflect discrete lineages or distinct states of a common cell type is not understood. Using single-cell RNA sequencing and flow cytometry, we focused on populations of TCF7⁺ cells that contained precursors for NK cells and ILC1s and identified a subset of bone marrow lineage-negative NK receptor-negative cells that expressed the transcription factor Eomes, termed Eomes^hiNK^neg cells. Transfer of Eomes^hiNK^neg cells into Rag2^-/-Il2rg^-/-<

SUBMITTER: Liang Z 

PROVIDER: S-EPMC11409033 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature