Worldwide analysis of actionable genomic alterations in lung cancer and targeted pharmacogenomic strategies.

ABSTRACT: Based on data from the Global Cancer Statistics 2022, lung cancer stands as the most lethal cancer worldwide, with age-adjusted incidence and mortality rates of 23.6 and 16.9 per 100,000 people, respectively. Despite significant strides in precision oncology driven by large-scale international research consortia, there remains a critical need to deepen our understanding of the genomic landscape across diverse racial and ethnic groups. To address this challenge, we performed comprehensive in silico analyses and data mining to identify pathogenic variants in genes that drive lung cancer. We subsequently calculated the allele frequencies and assessed the deleteriousness of these oncogenic variants among populations such as African, Amish, Ashkenazi Jewish, East and South Asian, Finnish

SUBMITTER: Echeverria-Garces G 

PROVIDER: S-EPMC11409134 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature