Exosome Loaded Protein Hydrogel for Enhanced Gelation Kinetics and Wound Healing.

ABSTRACT: Exosomes are being increasingly explored in biomedical research for wound healing applications. Exosomes can improve blood circulation and endocrine signaling, resulting in enhanced cell regeneration. However, exosome treatments suffer from low retention and bioavailability of exosomes at the wound site. Hydrogels are a popular tool for drug delivery due to their ability to encapsulate drugs in their network and allow for targeted release. Recently, hydrogels have proven to be an effective method to provide increased rates of wound healing when combined with exosomes that can be applied noninvasively. We have designed a series of single-domain protein-based hydrogels capable of physical cross-linking and upper critical solution temperature (UCST) behavior. Hydrogel variant Q5, previously d

SUBMITTER: Britton D 

PROVIDER: S-EPMC11409212 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature