Causality of blood metabolites and metabolic pathways on peripheral arteriosclerosis: a Mendelian randomization study.

ABSTRACT:

Background

Peripheral arteriosclerosis is caused by any atherosclerosis outside the heart and brain. However, the underlying biological mechanisms are not fully understood. This study aims to explore the causal relationship between blood metabolites and peripheral arteriosclerosis.

Methods

A Mendelian randomization (MR) analysis was implemented to estimate the causality of blood metabolites on peripheral arteriosclerosis. A genome-wide association study (GWAS) of 1,400 metabolites was used as the exposure, whereas two different GWAS datasets of peripheral arteriosclerosis were the outcomes. Inverse-variance weighted (IVW) was the main analysis of causal analysis. MR-Egger, the simple mode, weighted median and weighted mode were used to increase the stability and robustness o

SUBMITTER: Ye Q 

PROVIDER: S-EPMC11409423 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature