Diagnostic value and correlation analysis of serum cytokine levels in patients with multiple system atrophy.

ABSTRACT:

Background

The association between cytokines in peripheral blood and clinical symptoms of multiple system atrophy (MSA) has been explored in only a few studies with small sample size, and the results were obviously controversial. Otherwise, no studies have explored the diagnostic value of serum cytokines in MSA.

Methods

Serum cytokines, including interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-α), were measured in 125 MSA patients and 98 healthy controls (HCs). Correlations of these serum cytokines with clinical variables were analyzed in MSA patients. Diagnostic value of cytokines for MSA was plotted by receiver operating curves.

Results

No significant differences were found in sex and age between the MSA group and the HCs. TNF-α in M

SUBMITTER: Chen X 

PROVIDER: S-EPMC11409425 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature