Exploring antibiotic-induced persister formation and bacterial persistence genes in clinical isolates from Burkina Faso.

ABSTRACT:

Background

In addition to antibiotic resistance, persistence is another cause of treatment failure in bacterial infections, representing a significant public health concern. Due to a lack of adequate data on clinical isolates, this study was initiated to investigate persistence in clinical isolates in Burkina Faso.

Methods

Eighty (80) clinical isolates, including 32 Pseudomonas aeruginosa, 41 Staphylococcus aureus, and 7 Salmonella sp. obtained from clinical laboratories in Burkina Faso, were analyzed to assess their susceptibility to ciprofloxacin and gentamicin, as well as to determine the presence of persistence genes. The effects of ciprofloxacin and gentamicin on persister formation were evaluated by conducting colony counts at 1, 3, 5, 7, and 20 h after exposing the ba

SUBMITTER: Konkobo A 

PROVIDER: S-EPMC11409487 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature