Truncated mini LRP1 transports cargo from luminal to basolateral side across the blood brain barrier.

ABSTRACT:

Background

The most crucial area to focus on when thinking of novel pathways for drug delivery into the CNS is the blood brain barrier (BBB). A number of nanoparticulate formulations have been shown in earlier research to target receptors at the BBB and transport therapeutics into the CNS. However, no mechanism for CNS entrance and movement throughout the CNS parenchyma has been proposed yet. Here, the truncated mini low-density lipoprotein receptor-related protein 1 mLRP1_DIV* was presented as blood to brain transport carrier, exemplified by antibodies and immunoliposomes using a systematic approach to screen the receptor and its ligands' route across endothelial cells in vitro.

Methods

The use of mLRP1_DIV* as liposomal carrier into the CNS was validated based on internali

SUBMITTER: Fritzen L 

PROVIDER: S-EPMC11409491 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature