Antifungal activities of Equol against Candida albicans in vitro and in vivo.

ABSTRACT: Candida albicans is an opportunistic fungal pathogen that can cause systemic infections in immunocompromised individuals. Morphological transition and biofilm formation are major virulence factors of C. albicans. Moreover, biofilm enhances resistance to antifungal agents. Therefore, it is urgent to identify new and effective compounds to target the biofilm of C. albicans. In the present study, the antifungal activities of equol against C. albicans were investigated. In vitro, the microdilution analysis and spot assay result showed that equol exhibited potent inhibitory activities against C. albicans. Further investigations confirmed that the antifungal effects of equol involved interference with the transition from yeast to hypha and biofilm format

SUBMITTER: Wang F 

PROVIDER: S-EPMC11409501 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature