N-acetylcysteine promotes doxycycline resistance in the bacterial pathogen Edwardsiella tarda.

ABSTRACT: Bacterial resistance poses a significant threat to both human and animal health. N-acetylcysteine (NAC), which is used as an anti-inflammatory, has been shown to have distinct and contrasting impacts on bacterial resistance. However, the precise mechanism underlying the relationship between NAC and bacterial resistance remains unclear and requires further investigation. In this study, we study the effect of NAC on bacterial resistance and the underlying mechanisms. Specifically, we examine the effects of NAC on Edwardsiella tarda ATCC15947, a pathogen that exhibits resistance to many antibiotics. We find that NAC can promote resistance of E. tarda to many antibiotics, such as doxycycline, resulting in an increase in the bacterial survival rate. Through proteomic analysis, we

SUBMITTER: Guo J 

PROVIDER: S-EPMC11409502 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature