A Two-Sample Mendelian Randomization Study of Neuroticism and Sleep Bruxism.

ABSTRACT: Sleep bruxism (SB) affects a considerable part of the population and is associated with neuroticism, stress, and anxiety in various studies. However, the causal mechanisms between neuroticism and SB have not been examined. Understanding the reasons for SB is important as understanding bruxism may allow improved comprehensive management of the disorders and comorbidities related to it. Previous studies on the association of risk factors to SB have provided important symptomatic insight but were mainly questionnaire based or limited in sample size and could not adequately assess causal relationships. The aim of this study was to elaborate the possible causal relationship of neuroticism as a risk factor for SB through a Mendelian randomization (MR) approach by combining questionnaires, regist

SUBMITTER: Strausz T 

PROVIDER: S-EPMC11409563 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature