Reperfusion therapies for ischemic stroke in dementia and cognitive impairment: A systematic review and meta-analysis.

ABSTRACT:

Background

Endovascular thrombectomy (EVT) and intravenous thrombolysis (IVT) have an unclear benefit in those with pre-stroke dementia or cognitive impairment, as these patients were often excluded from landmark stroke trials. We performed a systematic review and meta-analysis to assess the outcomes of IVT and EVT in these populations.

Aims

Our systematic review, conforming to the Meta-Analysis of Observational Studies in Epidemiology guidelines, investigated studies on acute ischemic stroke patients with pre-stroke dementia or cognitive impairment treated with IVT or EVT. Primary outcome was favorable 90-day outcome (mRS 0-2). Secondary outcomes included 90-day mortality, symptomatic intracranial hemorrhage (SICH), and radiographic intracranial hemorrhage (ICH).

Summary

SUBMITTER: Bala F 

PROVIDER: S-EPMC11409564 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature