SNAI1: a key modulator of survival in lung squamous cell carcinoma and its association with metastasis.

ABSTRACT:

Background

Snail family zinc finger 1 (SNAI1) has been implicated in cancer progression and prognosis across various malignancies. This study aims to elucidate the prognostic significance of SNAI1 expression in Lung Squamous Cell Carcinoma (LUSC) using data from The Cancer Genome Atlas (TCGA) database.

Methods

SNAI1 expression levels in LUSC patients were stratified using X-tile software to establish optimal cut-off values. Kaplan-Meier survival analysis was performed to assess the impact of SNAI1 expression on overall survival (OS). Univariate and multivariate Cox regression analyses were conducted to evaluate the prognostic value of SNAI1, considering clinical parameters such as age, clinical stage, and TNM classification. Additionally, we explored the interaction between

SUBMITTER: Li B 

PROVIDER: S-EPMC11409570 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature