Positive-unlabeled learning to infer protection status and identify correlates in vaccine efficacy field trials.

ABSTRACT: Correlates of protection (CoPs) are key guideposts that both support vaccine development and licensure as well as improve our understanding of the attributes of immune responses that may directly provide protection. Unfortunately, factors such as low rate of exposure and low efficacy can result in low power to discover correlates in field trials-making it difficult to identify these guideposts for the pathogens against which there is greatest need for further insights. To address this gap, we examine the ability of positive-unlabeled (PU) learning approaches to use immunogenicity data and infection status outcomes to accurately predict protection status. We report a combination of PU bagging and two-step reliable negative techniques that accurately classify the protection status of unlabel

SUBMITTER: Xu S 

PROVIDER: S-EPMC11409573 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature