International expert opinion on the considerations for combining vosoritide and limb surgery: a modified delphi study.

ABSTRACT:

Background

Achondroplasia is the most common form of skeletal disorder with disproportionate short stature. Vosoritide is the first disease-specific, precision pharmacotherapy to increase growth velocity in children with achondroplasia. Limb surgery is a standard approach to increase height and arm span, improve proportionality and functionality, as well as correcting deformities. The aim of this study was to gain expert opinion on the combined use of vosoritide and limb surgery in children and adolescents with achondroplasia.

Methods

An international expert panel of 17 clinicians and orthopaedic surgeons was convened, and a modified Delphi process undertaken. The panel reviewed 120 statements for wording, removed any unnecessary statements, and added any that they felt were

SUBMITTER: Boero S 

PROVIDER: S-EPMC11409630 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature