Genetic diversity, biofilm formation, and Vancomycin resistance of clinical Clostridium innocuum isolates.

ABSTRACT:

Background

Clostridium innocuum, previously considered a commensal microbe, is a spore-forming anaerobic bacterium. C. innocuum displays inherent resistance to vancomycin and is associated with extra-intestinal infections, antibiotic-associated diarrhea, and inflammatory bowel disease. This study seeks to establish a multilocus sequence typing (MLST) scheme to explore the correlation between C. innocuum genotyping and its potential pathogenic phenotypes.

Methods

Fifty-two C. innocuum isolates from Linkou Chang Gung Memorial Hospital (CGMH) in Taiwan and 60 sequence-available C. innocuum isolates from the National Center for Biotechnolgy Information Genome Database were included. The concentrated sequence of housekeeping genes in C. innocuum was determined by amplicon sequenc

SUBMITTER: Chiang-Ni C 

PROVIDER: S-EPMC11409672 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature