The involvement and significance of M2 macrophages in neuropathic pain following spinal cord injury: a systematic review.

ABSTRACT: Neuropathic pain (NeP) is a type of persistent pain initiated by diseases or injuries of the nervous system. Although the underlying pathophysiological mechanisms of NeP are poorly understood, the immune system plays a key role in this condition. M2 macrophages have a key role in tissue healing and the reduction of inflammation. This systematic study aims to provide an overview of the role and importance of M2 macrophages in NeP after spinal cord injury (SCI). A comprehensive systematic review was conducted utilizing Scopus, PubMed, Embase, and ISI Web of Science databases. Two independent reviewers conducted the article selection. All publications examine the impact of M2 macrophages on NeP following spinal cord injuries. A quality assessment was conducted on bias entities that had been p

SUBMITTER: Shahrezaei A 

PROVIDER: S-EPMC11409760 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature