Diurnal timing of physical activity and risk of colorectal cancer in the UK Biobank.

ABSTRACT:

Background

Physical activity reduces colorectal cancer risk, yet the diurnal timing of physical activity in colorectal cancer etiology remains unclear.

Methods

This study used 24-h accelerometry time series from UK Biobank participants aged 42 to 79 years to derive circadian physical activity patterns using functional principal component analysis. Multivariable Cox proportional hazard models were used to examine associations with colorectal cancer risk.

Results

Among 86,252 participants (56% women), 529 colorectal cancer cases occurred during a median 5.3-year follow-up. We identified four physical activity patterns that explained almost 100% of the data variability during the day. A pattern of continuous day-long activity was inversely associated with colorectal canc

SUBMITTER: Stein MJ 

PROVIDER: S-EPMC11409794 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature