Cyclic stretch enhances neutrophil extracellular trap formation.

ABSTRACT:

Background

Neutrophils, the most abundant leukocytes circulating in blood, contribute to host defense and play a significant role in chronic inflammatory disorders. They can release their DNA in the form of extracellular traps (NETs), which serve as scaffolds for capturing bacteria and various blood cells. However, uncontrolled formation of NETs (NETosis) can lead to excessive activation of coagulation pathways and thrombosis. Once neutrophils are migrated to infected or injured tissues, they become exposed to mechanical forces from their surrounding environment. However, the impact of transient changes in tissue mechanics due to the natural process of aging, infection, tissue injury, and cancer on neutrophils remains unknown. To address this gap, we explored the interactive effect

SUBMITTER: Khanmohammadi M 

PROVIDER: S-EPMC11409804 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature