Genetically predicted dietary intake and risks of colorectal cancer: a Mendelian randomisation study.

ABSTRACT:

Background

Effects of confounders on associations between diet and colorectal cancer (CRC) in observational studies can be minimized in Mendelian randomization (MR) approach. This study aimed to investigate observational and genetically predicted associations between dietary intake and CRC using one-sample MR.

Methods

Using genetic data of over 93 million variants, we performed a genome-wide association study to find genomic risk loci associated with dietary intake in participants from the UK Biobank. Then we calculated genetic risk scores of diet-related variants and used them as instrumental variables in the two-stage least square MR framework to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for associations. We also performed observational analyses u

SUBMITTER: Hoang T 

PROVIDER: S-EPMC11409808 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature