Altered microbial diversity and composition of multiple mucosal organs in cervical cancer patients.

ABSTRACT:

Objectives

The aim of this study was to characterize the microbiome of multiple mucosal organs in cervical cancer (CC) patients.

Methods

We collected oral, gut, urinary tract, and vaginal samples from enrolled study participants, as well as tumor tissue from CC patients. The microbiota of different mucosal organs was identified by 16S rDNA sequencing and correlated with clinical-pathological characteristics of cervical cancer cases.

Results

Compared with controls, CC patients had reduced α-diversity of oral and gut microbiota (p_{Oral_Sob} < 0.001, p_{Oral_Shannon} = 0.049, p_{Oral_Simpson} = 0.013 p_{Fecal_Sob} = 0.030), although there was an opposite trend in the vaginal microbiota (p_{Vaginal_Pielou} = 0.028, p_{Vaginal_Si}

SUBMITTER: Peng L 

PROVIDER: S-EPMC11409810 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature