Identifying subgroups of urge suppression in Obsessive-Compulsive Disorder using machine learning.

ABSTRACT: Obsessive-compulsive disorder (OCD) is phenomenologically heterogeneous. While predominant models suggest fear and harm prevention drive compulsions, many patients also experience uncomfortable sensory-based urges ("sensory phenomena") that may be associated with heightened interoceptive sensitivity. Using an urge-to-blink eyeblink suppression paradigm to model sensory-based urges, we previously found that OCD patients as a group had more eyeblink suppression failures and greater activation of sensorimotor-interoceptive regions than controls. However, conventional approaches assuming OCD homogeneity may obscure important within-group variability, impeding precision treatment development. This study investigated the heterogeneity of urge suppression failure in OCD and examined relationships

SUBMITTER: Eng GK 

PROVIDER: S-EPMC11409861 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature