Antiretroviral Therapy and Cardiovascular Risk in People With HIV in the United States-An Updated Analysis.

ABSTRACT:

Background

Several antiretroviral therapy (ART) medications have been associated with increased cardiovascular risk, but less is known about the safety of modern ART. We sought to compare the risk of major adverse cardiac events (MACEs) among different ART regimens.

Methods

Using insurance claims databases from 2008 to 2020, we identified adults aged <65 years who newly initiated ART. We compared non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens to protease inhibitors (PI)- and integrase inhibitors (INSTI)-based regimens. We used propensity score-weighted Kaplan-Meier functions to estimate the 6, 12, 18, 24, 36, and 48 months' risk and risk differences (RD) of MACE.

Results

Among 37 935 ART initiators (median age, 40 years; 23% female; 26% Medicaid

SUBMITTER: Parra-Rodriguez L 

PROVIDER: S-EPMC11409880 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature