CD8⁺ T cells exacerbate AD-like symptoms in mouse model of amyloidosis.

ABSTRACT: Alzheimer's disease (AD) is linked to toxic Aβ plaques in the brain and activation of innate responses. Recent findings however suggest that the disease may also depend on the adaptive immunity, as B cells exacerbate and CD8⁺ T cells limit AD-like pathology in mouse models of amyloidosis. Here, by artificially blocking or augmenting CD8⁺ T cells in the brain of 5xFAD mice, we provide evidence that AD-like pathology is promoted by pathogenic, proinflammatory cytokines and exhaustion markers expressing CXCR6⁺ CD39⁺CD73^+/- CD8⁺ T_RM-like cells. The CD8⁺ T cells appear to act by targeting disease associated microglia (DAM), as we find them in tight complexes with microglia around Aβ plaques in the brain of m

SUBMITTER: Wang X 

PROVIDER: S-EPMC11409913 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature