Morphoelastic models discriminate between different mechanisms of left-right asymmetric stomach morphogenesis.

ABSTRACT: The mechanisms by which the vertebrate stomach undergoes its evolutionarily conserved leftward bending remain incompletely understood. Although the left and right sides of the organ are known to possess different gene expression patterns and undergo distinct morphogenetic events, the physical mechanisms by which these differences generate morphological asymmetry remain unclear. Here, we develop a continuum model of asymmetric stomach morphogenesis. Using a morphoelastic framework, we investigate the morphogenetic implications of a variety of hypothetical, tissue-level growth differences between the left and right sides of a simplified tubular organ. Simulations reveal that, of the various differential growth mechanisms tested, only one category is consistent with the leftward stomach curva

SUBMITTER: Nikas AN 

PROVIDER: S-EPMC11409938 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature