Hybrid nanoparticle-mediated simultaneous ROS scavenging and STING activation improve the antitumor immunity of in situ vaccines.

ABSTRACT: In situ vaccine (ISV) is a versatile and personalized local immunotherapeutic strategy. However, the compromised viability and function of dendritic cells (DCs) in a tumor microenvironment (TME) largely limit the therapeutic efficacy. We designed a hybrid nanoparticle-based ISV, which accomplished superior cancer immunotherapy via simultaneously scavenging reactive oxygen species (ROS) and activating the stimulator of interferon genes (STING) pathway in DCs. This ISV was constructed by encapsulating a chemodrug, SN38, into diselenide bond-bridged organosilica nanoparticles, followed by coating with a Mn²⁺-based metal phenolic network. We show that this ISV can activate the STING pathway through Mn²⁺ and SN38 comediated signaling and simultaneously scavenge preexisting

SUBMITTER: Li J 

PROVIDER: S-EPMC11409974 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature