PFAS Levels, Early Life Factors, and Mammographic Breast Density in Premenopausal Women.

ABSTRACT:

Background

Mammographic breast density (MBD) is a strong risk factor and an intermediate phenotype for breast cancer, yet there are limited studies on how environmental pollutants are associated with MBD.

Objective

We investigated associations of perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), and perfluorohexane sulfonate (PFHxS) levels with measures of MBD and evaluated if early life factors modified any associations.

Methods

Metabolon performed metabolomics analysis using ultrahigh-performance liquid chromatography/tandem accurate mass spectrometry in fasting blood from 705 premenopausal women completing their annual screening mammogram in St. Louis, Missouri. We calculated least square means (LSM) of mammographic volumetric percent density (VPD),

SUBMITTER: Ning YS 

PROVIDER: S-EPMC11410150 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature