Advanced Overview of Biomarkers and Techniques for Early Diagnosis of Alzheimer's Disease.

ABSTRACT: The development of early non-invasive diagnosis methods and identification of novel biomarkers are necessary for managing Alzheimer's disease (AD) and facilitating effective prognosis and treatment. AD has multi-factorial nature and involves complex molecular mechanism, which causes neuronal degeneration. The primary challenges in early AD detection include patient heterogeneity and lack of precise diagnosis at the preclinical stage. Several cerebrospinal fluid (CSF) and blood biomarkers have been proposed to show excellent diagnosis ability by identifying tau pathology and cerebral amyloid beta (Aβ) for AD. Intense research endeavors are being made to develop ultrasensitive detection techniques and find potent biomarkers for early AD diagnosis. To mitigate AD worldwide, understanding vari

SUBMITTER: Rani S 

PROVIDER: S-EPMC11410160 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature