The sucrose challenge symptoms test optimized for diagnosis of congenital sucrase isomaltase deficiency.

ABSTRACT:

Background

Congenital sucrase isomaltase deficiency (CSID), an inherited carbohydrate malabsorption disorder, is difficult to diagnose because of overlapping symptoms with other gastrointestinal (GI) diseases. An at-home study was conducted in CSID and healthy adults to evaluate the diagnostic utility of self-reported GI symptoms following administration of a sucrose challenge.

Methods

This study investigated the optimum symptom scoring with a sucrose challenge symptoms test (SCST) for diagnosing CSID in 45 confirmed patients and 118 healthy controls. Subjects self-reported the severity of GI symptoms using a 10-point Likert scale after ingesting 50 grams of sucrose on an empty stomach. The receiver operator characteristics curve (ROC) was used to identify the diagnostic var

SUBMITTER: Street K 

PROVIDER: S-EPMC11410207 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature