Post-myocardial infarction heart failure and long-term high-fat diet: Cardiac endoplasmic reticulum stress and unfolded protein response in Sprague Dawley rat model.

ABSTRACT:

Background

Myocardial infarction (MI) significantly contributes to the global mortality rate, often leading to heart failure (HF) due to left ventricular remodeling. Key factors in the pathomechanism of HF include nitrosative/oxidative stress, inflammation, and endoplasmic reticulum (ER) stress. Furthermore, while a high-fat diet (HFD) is known to exacerbate post-MI cardiac remodeling, its impact on these critical factors in the context of HF is not as well understood.

Aims

This study aimed to assess the impact of post-MI HF and HFD on inflammation, nitro-oxidative stress, ER stress, and unfolded protein response (UPR).

Methods

The study was performed on fragments of the left ventricle harvested from 30 male adult Sprague Dawley rats, which were divided into four grou

SUBMITTER: Momot K 

PROVIDER: S-EPMC11410228 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature