HIV-1 diversity in viral reservoirs obtained from circulating T-cell subsets during early ART and beyond.

ABSTRACT: Even during extended periods of effective immunological control, a substantial dynamic of the viral genome can be observed in different cellular compartments in HIV-1 positive individuals, indicating the persistence of active viral reservoirs. To obtain further insights, we studied changes in the proviral as well as in the viral HIV-1 envelope (Env) sequence along with transcriptional, translational and viral outgrowth activity as indicators for viral dynamics and genomic intactness. Our study identified distinct reservoir patterns that either represented highly sequence-diverse HIV-1 populations or only a single / few persisting virus variants. The single dominating variants were more often found in individuals starting ART during early infection phases, indicating that early treatment mi

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11410260 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature