The role of bacterial size, shape and surface in macrophage engulfment of uropathogenic E. coli cells.

ABSTRACT: Uropathogenic Escherichia coli (UPEC) can undergo extensive filamentation in the host during acute urinary tract infections (UTIs). It has been hypothesised that this morphological plasticity allows bacteria to avoid host immune responses such as macrophage engulfment. However, it is still unclear what properties of filaments are important in macrophage-bacteria interactions. The aim of this work was to investigate the contribution of bacterial biophysical parameters, such as cell size and shape, and physiological parameters, such as cell surface and the environment, to macrophage engulfment efficiency. Viable, reversible filaments of known lengths and volumes were produced in the UPEC strain UTI89 using a variety of methods, including exposure to cell-wall targeting antibiotics, genetic m

SUBMITTER: Peterson E 

PROVIDER: S-EPMC11410268 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature