Cardiac Effects of Renin-Angiotensin System Inhibitors in Nonproteinuric CKD.

ABSTRACT:

Background

In contrast to proteinuric chronic kidney disease (CKD), the relative cardioprotective benefits of antihypertensive medications in nonproteinuric CKD are unknown. We examined long-term cardiovascular outcomes and mortality in patients with nonproteinuric CKD treated with renin-angiotensin system inhibitors (RASIs) versus other antihypertensive medications.

Methods

Among participants of the CRIC study (Chronic Renal Insufficiency Cohort) without proteinuria, we used intention-to-treat analyses with inverse probability of treatment weighting and Cox proportional hazards modeling to determine the association of RASIs versus other antihypertensive medications with a composite cardiovascular outcome (myocardial infarction, stroke, heart failure hospitalization, and dea

SUBMITTER: Shulman RS 

PROVIDER: S-EPMC11410532 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature