Gold Nanoparticle Transport in the Injured Kidneys with Elevated Renal Function Biomarkers.

ABSTRACT: Renal function biomarkers such as serum blood urea nitrogen (BUN) and creatinine (Cr) serve as key indicators for guiding clinical decisions before administering kidney-excreted small-molecule agents. With engineered nanoparticles increasingly designed to be renally clearable to expedite their clinical translation, understanding the relationship between renal function biomarkers and nanoparticle transport in diseased kidneys becomes crucial to their biosafety in future clinical applications. In this study, renal-clearable gold nanoparticles (AuNPs) are used as X-ray contrast agents to noninvasively track their transport and retention in cisplatin-injured kidneys with varying BUN and Cr levels. The findings reveal that AuNP transport is significantly slowed in the medulla of severely injure

SUBMITTER: Ning X 

PROVIDER: S-EPMC11410533 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature