Acute renal response to changes in carbon dioxide in mechanically ventilated female pigs.

ABSTRACT: Kidney response to acute and mechanically induced variation in ventilation associated with different levels of PEEP has not been investigated. We aimed to quantify the effect of ventilatory settings on renal acid-base compensation. Forty-one pigs undergoing hypo- (<0.2 Lkg^-1 min^-1, PEEP 25 cmH₂O), intermediate (0.2-0.4 Lkg^-1 min^-1 with either PEEP 5 or 25 cmH₂O), or hyper-ventilation (>0.4 Lkg^-1 min^-1, PEEP 5 cmH₂O) for 48 h were retrospectively included. The decrease in pH paralleled the decrease in plasma strong ion difference (SID) in hyper- and intermediately ventilated groups with lower PEEP. In contrast, the plasma SID remained nearly constant in hypo- and intermediately ventilated grou

SUBMITTER: Pozzi T 

PROVIDER: S-EPMC11410556 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature