Thyroid dysfunction and sarcopenia: a two-sample Mendelian randomization study.

ABSTRACT:

Objective

Observational studies have shown positive associations between thyroid dysfunction and risk of sarcopenia. However, the causality of this association remains unknown. This study aimed to evaluate the potential causal relationship between thyroid dysfunction and sarcopenia using Mendelian randomization (MR).

Methods

This study collected pooled data from genome-wide association studies focusing on thyroid dysfunction and three sarcopenia-related features: low hand grip strength, appendicular lean mass (ALM), and walking pace, all in individuals of European ancestry. The primary analytical method used was inverse-variance weighted, with weighted median and MR-Egger serving as complementary methods to assess causal effects. Heterogeneity and pleiotropy tests were also

SUBMITTER: Wei J 

PROVIDER: S-EPMC11410624 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature