Biphasic response of human iPSC-derived neural network activity following exposure to a sarin-surrogate nerve agent.

ABSTRACT: Organophosphorus nerve agents (OPNA) are hazardous environmental exposures to the civilian population and have been historically weaponized as chemical warfare agents (CWA). OPNA exposure can lead to several neurological, sensory, and motor symptoms that can manifest into chronic neurological illnesses later in life. There is still a large need for technological advancement to better understand changes in brain function following OPNA exposure. The human-relevant in vitro multi-electrode array (MEA) system, which combines the MEA technology with human stem cell technology, has the potential to monitor the acute, sub-chronic, and chronic consequences of OPNA exposure on brain activity. However, the application of this system to assess OPNA hazards and risks to human brain function re

SUBMITTER: Bogguri C 

PROVIDER: S-EPMC11410629 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature