Vaccine induced mucosal and systemic memory NK/ILCs elicit decreased risk of SIV/SHIV acquisition.

ABSTRACT: SIV and HIV-based envelope V1-deleted (ΔV1) vaccines, delivered systemically by the DNA/ALVAC/gp120 platform, decrease the risk of mucosal SIV or SHIV acquisition more effectively than V1-replete vaccines. Here we investigated the induction of mucosal and systemic memory-like NK cells as well as antigen-reactive ILC response by DNA/ALVAC/gp120-based vaccination and their role against SIV/SHIV infection. ΔV1 HIV vaccination elicited a higher level of mucosal TNF-α⁺ and CD107⁺ memory-like NK cells than V1-replete vaccination, suggesting immunogen dependence. Mucosal memory-like NK cells, systemic granzyme B⁺ memory NK cells, and vaccine-induced mucosal envelope antigen-reactive IL-17⁺ NKp44⁺ ILCs, IL-17⁺ ILC3s, and IL-13⁺

SUBMITTER: Rahman MA 

PROVIDER: S-EPMC11410642 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature