Agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone.

ABSTRACT: Heart failure is a leading cause of morbidity and mortality^1,2. Elevated intracardiac pressures and myocyte stretch in heart failure trigger the release of counter-regulatory natriuretic peptides, which act through their receptor (NPR1) to affect vasodilation, diuresis and natriuresis, lowering venous pressures and relieving venous congestion^3-8. Recombinant natriuretic peptide infusions were developed to treat heart failure but have been limited by a short duration of effect^9,10. Here we report that in a human genetic analysis of over 700,000 individuals, lifelong exposure to coding variants of the NPR1 gene is associated with changes in blood pressure and risk of heart failure. We describe the development of REGN5381, an investigational monoclonal agonist

SUBMITTER: Dunn ME 

PROVIDER: S-EPMC11410649 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature