Frontostriatal salience network expansion in individuals in depression.

ABSTRACT: Decades of neuroimaging studies have shown modest differences in brain structure and connectivity in depression, hindering mechanistic insights or the identification of risk factors for disease onset¹. Furthermore, whereas depression is episodic, few longitudinal neuroimaging studies exist, limiting understanding of mechanisms that drive mood-state transitions. The emerging field of precision functional mapping has used densely sampled longitudinal neuroimaging data to show behaviourally meaningful differences in brain network topography and connectivity between and in healthy individuals^2-4, but this approach has not been applied in depression. Here, using precision functional mapping and several samples of deeply sampled individuals, we found that the frontostriatal

SUBMITTER: Lynch CJ 

PROVIDER: S-EPMC11410656 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature