Mapping glycoprotein structure reveals Flaviviridae evolutionary history.

ABSTRACT: Viral glycoproteins drive membrane fusion in enveloped viruses and determine host range, tissue tropism and pathogenesis¹. Despite their importance, there is a fragmentary understanding of glycoproteins within the Flaviviridae², a large virus family that include pathogens such as hepatitis C, dengue and Zika viruses, and numerous other human, animal and emergent viruses. For many flaviviruses the glycoproteins have not yet been identified, for others, such as the hepaciviruses, the molecular mechanisms of membrane fusion remain uncharacterized³. Here we combine phylogenetic analyses with protein structure prediction to survey glycoproteins across the entire Flaviviridae. We find class II fusion systems, homologous to the Orthoflavivirus E glycoprotein in mo

SUBMITTER: Mifsud JCO 

PROVIDER: S-EPMC11410658 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature