Validation of a whole slide image management system for metabolic-associated steatohepatitis for clinical trials.

ABSTRACT: The gold standard for enrollment and endpoint assessment in metabolic dysfunction-associated steatosis clinical trials is histologic assessment of a liver biopsy performed on glass slides. However, obtaining the evaluations from several expert pathologists on glass is challenging, as shipping the slides around the country or around the world is time-consuming and comes with the hazards of slide breakage. This study demonstrated that pathologic assessment of disease activity in steatohepatitis, performed using digital images on the AISight whole slide image management system, yields results that are comparable to those obtained using glass slides. The accuracy of scoring for steatohepatitis (nonalcoholic fatty liver disease activity score ≥4 with ≥1 for each feature and absence of atypical

SUBMITTER: Pulaski H 

PROVIDER: S-EPMC11410674 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature