Casual effects of type 1 diabetes mellitus on site-specific digestive cancers: a Mendelian randomisation analysis.

ABSTRACT:

Objective

Despite several observational studies attempting to investigate the potential association between type 1 diabetes mellitus (T1DM) and the risk of digestive cancers, the results remain controversial. The purpose of this study is to examine whether there is a causal relationship between T1DM and the risk of digestive cancers.

Methods

We conducted a Mendelian randomisation (MR) study to systematically investigate the effect of T1DM on six most prevalent types of digestive cancers (oesophageal cancer, stomach cancer, hepatocellular carcinoma, biliary tract cancer, pancreatic cancer, and colorectal cancer). A total of 1,588,872 individuals were enrolled in this analysis, with 372,756 being the highest number for oesophageal cancer and 3,835 being the lowest for pancreat

SUBMITTER: Zhao J 

PROVIDER: S-EPMC11410686 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature