Identification and validation of a novel five-gene signature in high-risk MYCN-not-amplified neuroblastoma.

ABSTRACT:

Objective

High-risk neuroblastoma patients often have poor outcomes despite multi-treatment options. The risk stratification of high-risk MYCN-not-amplified (HR-MYCN-NA) patients remains difficult. This study aims to identify a gene set signature that can help further stratify HR-MYCN-NA patients for a potential personalized therapeutic strategy.

Methods

Three microarrays and one single-cell RNA sequence dataset were acquired and analyzed. Firstly, the prognostic-related genes (PRGs) in HR-MYCN-NA tumor cells were identified using TARGET-NB and GSE137804 datasets. Then, the prognostic model was established by LASSO-Cox regression, and verified in external cohort (GSE49710, GSE45547). Moreover, a time-dependent receiver operating characteristic curve (ROC) and area under the

SUBMITTER: Wang JX 

PROVIDER: S-EPMC11410741 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature