Exploring family communication preferences in hereditary breast and ovarian cancer and Lynch syndrome: a national Canadian survey.

ABSTRACT:

Background

Individuals affected with cancer predisposition (CPS) syndromes such as BRCA1, BRCA2 or Lynch syndrome (LS) are at an elevated risk of multiple cancers. Identifying high-risk individuals is important if they are to access risk-reducing strategies. Interventions such as risk-reducing salpingo-oophorectomy in carriers of BRCA pathogenic or likely pathogenic (P/LP) variants or regular colonoscopy for carriers of LS P/LP variants are highly effective and reduce mortality. Despite clear evidence that the identification of at-risk relatives has value, the uptake of cascade testing remains at approximately 50%. It is important to understand strategies and barriers to testing to facilitate communication in families identified as haveing a hereditary cancer syndrome, to improve u

SUBMITTER: Burke K 

PROVIDER: S-EPMC11410744 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature