Baseline prognostic predictors in classical Hodgkin Lymphoma: a retrospective, single-center analysis on patients treated with PET/CT-guided ABVD.

ABSTRACT:

Introduction

The identification of baseline prognostic factors in Classical Hodgkin Lymphoma could help in tailoring a risk-based approach as the therapeutic landscape expands. Currently, the International Prognostic Score (IPS) represents the most used prediction tool in clinical practice, but other potential baseline risk predictors have been identified.

Methods

We performed a retrospective analysis in a cohort of 274 patients treated with ¹⁸FDG-PET/CT-guided ABVD to assess the prognostic significance of the IPS risk factors, and to validate the impact of the peripheral blood lymphocyte to monocyte (LMR) and neutrophil to lymphocyte (NLR) ratios on prognosis definition.

Results

Among the considered risk factors, stage IV disease (HR 1.83), leukocytosis (H

SUBMITTER: Cellini A 

PROVIDER: S-EPMC11410762 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature