Positive Intervention of Distinct Peptides in Clostridioides difficile Infection in a Mouse Model.

ABSTRACT: Clostridioides difficile infection (CDI) is a common healthcare-associated infection and the leading cause of gastroenteritis-related deaths worldwide. To investigate the effects of peptide composition of different protein products on CDI, we analyzed and compared the peptide sequences and compositions from Engraulis japonicus and Glycine max using Ultra High Performance Liquid Chromatography Tandem Mass Spectrometry (UPLC-MS/MS). An animal model of CDI was also established to investigate the potential therapeutic effects of these peptides in vivo. The peptide compositions of E. japonicus and G. max differed, with only 11% of the peptide sequences being identical. Oral administration of the tested peptides could reduce intestinal inflammation, repair the intestinal barrier, increase the pr

SUBMITTER: Li Y 

PROVIDER: S-EPMC11410834 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature