Gut microbiome shifts in people with type 1 diabetes are associated with glycaemic control: an INNODIA study.

ABSTRACT:

Aims/hypothesis

The gut microbiome is implicated in the disease process leading to clinical type 1 diabetes, but less is known about potential changes in the gut microbiome after the diagnosis of type 1 diabetes and implications in glucose homeostasis. We aimed to analyse potential associations between the gut microbiome composition and clinical and laboratory data during a 2 year follow-up of people with newly diagnosed type 1 diabetes, recruited to the Innovative approaches to understanding and arresting type 1 diabetes (INNODIA) study. In addition, we analysed the microbiome composition in initially unaffected family members, who progressed to clinical type 1 diabetes during or after their follow-up for 4 years.

Methods

We characterised the gut microbiome composition of 9

SUBMITTER: Vatanen T 

PROVIDER: S-EPMC11410864 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature