Causal relationship between insomnia and thyroid disease: A bidirectional Mendelian randomization study.

ABSTRACT:

Objective

Some correlations between thyroid disorders and insomnia have been found in previous studies; however, the causal relationship between them is unclear. The aim of this study was to investigate the causal relationship between insomnia and five thyroid disorders (hyperthyroidism, hypothyroidism, thyroiditis, thyroid nodules, and thyroid cancer).

Methods

We assessed the causal relationship between insomnia and thyroid disorders using inverse variance weighted, weighted median, and Mendelian randomization (MR)-Egger analyses in MR analyses and then used inverse MR analyses to assess the causal relationship between thyroid disorders and insomnia.

Results

MR analysis showed that insomnia did not increase the risk of hyperthyroidism, hypothyroidism, thyroiditis, th

SUBMITTER: Li Z 

PROVIDER: S-EPMC11410884 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature